METHOD FOR DETERMINING THE CONFIGURATION OF INTERFERING FILTRATION MEDIUM FOR AN OPTICAL DEVICE AND

专利摘要:
method for determining the setting of an ophthalmic filter. a method for determining the interfering filter media configuration for an optical device comprising an optical substrate for a user, the method comprising: providing a first set of parameters representative of at least one main line of sight of the user, the distance between the optical substrate and a user's eye, a size of a retinal area and/or the pupil size of the user's eye; determining a first selected range of angles of incidence based on the first set of parameters; providing a second set of parameters that characterize, to the user, a range of wavelengths to be inhibited, at least partially; determining a first selected range of incident light wavelengths to be inhibited, at least partially, based on the second set of parameters; and configuring a first selective interfering filtering means and a first zone of a surface of the optical substrate based on the first selected range of incidence angles and the first selected range of wavelengths such that the first selective interfering filtering means is operable to inhibit, at a first rejection rate, the transmission of the first selected range of wavelengths of incident light incident on the first zone within the first selected range of angles of incidence.
公开号:BR112014013839B1
申请号:R112014013839-7
申请日:2012-12-06
公开日:2022-01-11
发明作者:Denis Cohen-Tannoudji；Coralie Barrau；Thierry Pierre Villette；José-Alain Sahel；Serge Picaud；Emilie Arnault
申请人:Essilor International；Sorbonne Universite；
IPC主号:

专利说明:

FIELD OF THE INVENTION
[0001] The present invention relates generally to an optical device comprising an optical substrate and the use of such an optical device. Embodiments of the invention relate to a method of determining a configuration for an optical device, a method of manufacturing an optical device, and using an optical device. BACKGROUND OF THE INVENTION
[0002] The electromagnetic spectrum covers a wide range of wavelengths, among which are the wavelengths visible to the human eye, often referred to as the visible spectrum, which covers a range from 380 nm to 780 nm. Some wavelengths in the electromagnetic spectrum which includes those in the visible spectrum provide harmful effects, while others are known to have beneficial effects on the eye. Some wavelengths in the visible spectrum are also known to induce a range of neuroendocrine, physiological, and behavioral responses known as non-imaging responses.
[0003] The vertebrate retina is a light-sensitive tissue that lines the inner surface of the eye. This tissue has four main layers from the vitreous to the choroid: the retinal pigment epithelium (hereinafter referred to as “RPE”), the photoreceptor layer (including rods and cones), the inner nuclear layer with amacrine and bipolar cells, and finally, the ganglion cell layer that contains some intrinsically photosensitive ganglion cells (1% retinal ganglion cells (hereinafter referred to as “RGC”)). This last cell type is important for circadian photic entrainment (biological rhythms) and pupillary function.
[0004] Neural signals begin in rods and cones and undergo complex processing by other retinal neurons. The output of processing takes the form of action potentials in retinal ganglion cells, in which the axons form the optic nerve. Several important features of visual perception can be directed towards processing light and encoding the retina.
[0005] Photobiology, which is the study of the biological effect of light, has established that a portion of the electromagnetic spectrum provides beneficial effects for good health, including visual perception and circadian functions. However, it also established the importance of protecting the eyes from harmful radiation such as ultraviolet (UV) rays. Visible light, even of ordinary daily intensity, can damage the retina or contribute to the development of early or late age-related maculopathy (ARM), such as Age-Related Macular Degeneration (AMD). There are indications in some epidemiological studies that the level of exposure to sunlight may be associated with the development of AMD: Tomany SC et al. Sunluz and the 10-Year Incidence of Age-Related Maculopathy. The Beaver Dam Eye Study. Arch Ophthalmol. 2004;122:750 to 757.
[0006] Other pathologies are related to exposure to light. For example, the production of melatonin in circadian rhythms is known to be regulated by exposure to light. As a consequence, the modification of specific light in the environment can impact the synchronization of the body's biological clock. Migraines are associated with photophobia, which is an abnormal intolerance to light stimulation of the visual system, and epilepsy can be affected by the presence of light.
[0007] Ophthalmic devices that filter out harmful UV radiation of low selectivity are widely used. For example, sunglasses are designed to provide sun protection by protecting the eye from the harmful effects of UVA and UVB rays. Intraocular lenses (IOLs) with UV filters were introduced in the 1990s; and they are the main implants after cataract surgery that replace the crystalline lens.
[0008] The present invention was conceived with the foregoing in mind. SUMMARY OF THE INVENTION
[0009] In accordance with a first aspect of the invention, there is provided a method of determining the configuration of interfering filter media for an optical device comprising an optical substrate for a user, wherein the method comprises: providing a first set of parameters representative of at least one primary line of sight of the wearer, the distance between the optical substrate and a wearer's eye, a size of a retinal area and/or the pupil size of the wearer's eye; determining a first selected range of angles of incidence based on the first set of parameters; providing a second set of parameters that characterize, to the user, a range of wavelengths to be inhibited, at least partially; determining a first selected range of incident light wavelengths to be inhibited, at least partially, based on the second set of parameters; and configuring a first selective interfering filter medium and a first zone of a surface of the optical substrate based on the first selected range of incidence angles and the first selected range of wavelengths such that the first selective interference filter medium is operable to inhibit, at a first rejection rate, the transmission of the first selected range of wavelengths of incident light incident on the first zone within the first selected range of angles of incidence.
[0010] In this way, an optical device can be customized for one or more users and for the intended use. Thus, an optical device is equipped with a selective interfering filtering medium that provides selective inhibition of incident light transmission in a spectral range of choice and configured to ensure better control of the spectral response obtained when uncollimated incident light reaches a geometric zone. defined optical substrate. The angular sensitivity of the interfering filter is first taken into account by considering a certain range of incidence angles, called the cone of incidence angles, to design the filters and not just a unique angle of incidence.
[0011] The selectivity and angular sensitivity control provided by the designed interfering filtration media minimizes color perception distortion, scotopic vision disturbance and limits the impact on non-visual eye functions. Furthermore, the yellowing effect provided by a broad long-pass absorbing filter of blue light can be avoided.
[0012] In one embodiment, the first and/or second set of parameters additionally comprise physiological parameters of the wearer such as whether the wearer suffers from eye deterioration or must be protected against eye deterioration.
[0013] The optical device can be designed according to the user's level of preventive needs and configured for particular illness or illnesses and/or stages of illness or illnesses suffered by the individual.
[0014] For example, deterioration of the eye may in particular be due to a degenerative process such as glaucoma, diabetic retinopathy, Leber's hereditary optic neuropathy, Age-related Macular Degeneration (AMD), Stargardt's disease, retinitis pigmentosa or Best.
[0015] The selective interfering filtration media can be adapted according to the disease or diseases or the stage of disease or diseases suffered by a user. For example, the area of the retina to be protected may change according to the stage of the disease. In this way, the range of angles of incidence on the surface of the optical substrate can be configured accordingly. In the case of advanced AMD, clinical data showed that a 25° angular cone centered on the fovea could be injured by the disease.
[0016] In a particular embodiment of the invention, the method includes providing at least a first additional set of parameters that define at least one additional primary line of sight of the user, the distance between the optical substrate and the user's eye, the size of an area of retina centered on the fovea of the wearer's eye and/or the pupil size of the wearer's eye; determining, for the or each additional first set of parameters, a respective selected range of angles of incidence based on the respective first additional set of parameters; providing at least a second additional set of parameters that characterize, to the user, at least an additional range of wavelengths to be inhibited, at least partially; determining, for the or each additional second set of parameters, a respective selected range of incident light wavelengths to be inhibited, at least partially, based on the respective second additional parameter set; and for the or each additional first parameter set and additional second parameter set: configure a respective additional selective interfering filter media and a respective additional optical substrate surface zone based on the respective selected range of incidence angles and the respective range wavelengths such that the respective additional selective interfering filter media is operable to inhibit, at a respective additional rejection rate, the transmission of the respective selected range of wavelengths of incident light incident on the respective additional zone within. of the respective selected range of angles of incidence.
[0017] In this way, multiple zones of the optical substrate can be configured according to sight lines and user requirements.
[0018] In one embodiment, the or each respective selected range of incidence angles is different from the first selected range of incidence angles. The or each respective selected range of wavelengths may be substantially the same as the first selected range of wavelengths. In this way, different cones of incident angles according to the geometric zone can be configured to provide the same controlled spectral response over the optical substrate surface almost independently of the incident angle.
[0019] In one embodiment, the first bounce rate is in a range of 10% to 100%, preferably 30% to 100%. The device can thus be configured for user and contemplated use.
[0020] Each additional bounce rate can be configured to be different from the first bounce rate. For example, the rejection rate may decrease with the distance of the zone from the overall center of the optical substrate. In this way, color perception distortion can be minimized.
[0021] In one embodiment, the optical device is an optical lens and the method includes configuring the first zone to correspond to a far vision portion of the optical lens for a wearer and an additional zone to correspond to a near vision portion of the lens optics for a user,
[0022] In one embodiment, the method includes configuring the or each selective interfering filtration media to inhibit incident light transmission by at least one of reflection, refraction, and diffraction.
[0023] In one embodiment, the first selected range of wavelengths has a bandwidth in a range of 20 nm to 60 nm, preferably 20 nm to 25 nm centered on a wavelength of substantially 435 nm, 445 nm or 460 nm and the first rejection rate is in a range of 10 to 50%, preferably 30 to 50%.
[0024] This allows for the selective filtration of wavelengths that have been shown by the inventors' groundbreaking studies to be harmful in cellular models for retinal diseases such as AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, glaucoma, diabetic retinopathy or Leber's hereditary optic neuropathy.
[0025] In fact, when investigating phototoxicity in RPE cells using primary cell model of AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, it was concluded by the investigators that the light was toxic to RPE cells at wavelengths of visible light centered around 435 nm. In experimental studies, toxicity to RPE cells was demonstrated by 10 nm bandwidths of light stretching from 415 nm to 455 nm. Surprisingly, when retinal ganglion cells, which degenerate into glaucoma and diabetic retinopathy, were exposed to light, it was found that they degenerate as light centered at 460 nm with the greatest toxicities being observed between 445 nm and 475 nm. Illustrative experimental studies were performed using light that has a bandwidth of 10 nm. Accordingly, one or more embodiments of the invention may provide an optical device for filtering target wavelength ranges of light centered at 435 nm and/or 460 nm depending on the pathologies considered.
[0026] In some embodiments, the proposed optical devices can be configured to specifically block the target wavelength bands of visible light with narrow bandwidths. They can have a preventive or therapeutic application in the case of retinal diseases considered (AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, glaucoma, diabetic retinopathy, Leber's hereditary optic neuropathy).
[0027] Filtering narrow bands of light allows the effects of color vision disturbance, impact on scotopic vision and the possible disruption of circadian rhythms to be minimized.
[0028] A selective interfering filter means can be configured, for example, to selectively inhibit light in a narrow range of wavelengths centered on a wavelength around 435 nm. This range of wavelengths was demonstrated by the groundbreaking studies performed by the inventors when investigating the phototoxicity of RPE using a primary cell model of AMD to exhibit maximum toxicity for diseases such as AMD, Stargardt's disease, retinitis pigmentosa, Best's disease.
[0029] In another example, a selective interfering filtration medium can be configured, for example, to selectively inhibit light in a narrow range of wavelengths centered on a wavelength around 460 nm. This range of wavelengths has been demonstrated by groundbreaking studies performed by the inventors when investigating the phototoxicity of RGC using a primary cellular model of glaucoma to exhibit maximum toxicity for diseases such as glaucoma, diabetic retinopathy, hereditary optic neuropathy of Leber.
[0030] In another example a selective interfering filtration medium can be configured, for example, to selectively inhibit light over a wider range of wavelengths centered on a wavelength around 445 nm, thereby filtering , light that has been shown in studies on PE and RGC cell models to be toxic to the progress of diseases such as glaucoma, diabetic retinopathy, Leber's hereditary optic neuropathy, Age-related Macular Degeneration (AMD), Stargardt's disease, retinitis pigmentosa or Best's disease.
[0031] In addition, the selective interfering filtration medium can be configured, as a dual band filter to selectively inhibit light in a narrow range of wavelengths centered on a wavelength around 435 nm which has been demonstrated by the studies cellular model as being detrimental to the progression of AMD, Stargardt's disease, retinitis pigmentosa or Best's disease; and in a narrow range of wavelengths centered on a wavelength around 460 nm that has been shown by cell model studies to be detrimental to the progression of Glaucoma, Leber's hereditary optic neuropathy or diabetic retinopathy. This modality provides increased selectivity, thereby limiting color vision distortion and scotopic vision disturbance.
[0032] In another embodiment, the first selected range of wavelengths has a bandwidth in a range of 15 nm to 30 nm, preferably 15 nm to 25 nm centered on a wavelength of substantially 435 nm, 445 nm or 460 nm, and the first rejection rate is in a range of 60 to 100%, preferably 80 to 100%. The increased rejection rate provides enhanced protection, in particular, for those suffering from a condition such as AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, glaucoma, Leber's hereditary optic neuropathy or diabetic retinopathy, which helps to slow down the disease progress.
[0033] In some embodiments, the optical device can be configured to provide an additional function of inhibiting light transmission across the entire visible spectrum. In one embodiment, the optical device is configured to inhibit transmission of visible light across the entire visible spectrum at an inhibition rate in the range of 40% to 92%. In such an embodiment, the first selected range of wavelengths has a bandwidth in a range of 25 nm to 60 nm, preferably 25 nm to 35 nm centered on a wavelength of substantially 435 nm, 445 nm or 460 nm and the first rejection rate is set to provide at least 5% additional inhibition for the first selected range of wavelengths. The additional 5% inhibition is beyond the inhibition rate across the entire visible spectrum.
[0034] Such a configuration can be used, for example, in sun protection to prevent transmission of toxic light in the first selected range of wavelengths to a user's eye.
[0035] In one embodiment, the optical device is configured such that the first selected range of wavelengths is from 465 nm to 495 nm. In this way, the device can be used to protect at least part of an eye of a user suffering from a light-induced sleep disorder.
[0036] In another embodiment, the optical device is configured such that the first selected range of wavelengths is from 550 nm to 660 nm. In this way, the device can be used to protect at least part of an eye of a user who suffers from a color vision disorder.
[0037] In another embodiment, the optical device is configured such that the first selected range of wavelengths is from 590 nm to 650 nm, preferably 615 nm to 625 nm. In this way, the device can be used to protect at least part of an eye of a migraine sufferer.
[0038] In another embodiment, the optical device is configured such that the first selected range of wavelengths is from 560 nm to 600 nm. In this way, the device can be used to protect at least part of an eye of a user suffering from epilepsy.
[0039] A further aspect of the invention provides a method of manufacturing an optical lens, the method comprising the steps of providing a semi-finished optical lens that has an unfinished surface and an opposing surface, wherein the unfinished surface is a between a convex surface and a concave surface and the opposite surface is the other of a convex surface and a concave surface; determining the configuration of a selective interference filter media for the optical lens for a wearer; level the unfinished surface; and providing one of the surfaces with the selective interfering filtration medium; wherein the step of determining the configuration of selective interfering filtration media comprises a method of determining the configuration of selective interfering filtration media including the steps of providing a first set of parameters representative of at least a primary line of sight to the user, the distance between the optical substrate and a user's eye, a size of a retinal area and/or the pupil size of the user's eye; determining a first selected range of angles of incidence based on the first set of parameters; providing a second set of parameters that characterize, to the user, a range of wavelengths to be inhibited, at least partially; determining a first selected range of incident light wavelengths to be inhibited, at least partially, based on the second set of parameters; and configuring a first selective interfering filter medium and a first zone of a surface of the optical substrate based on the first selected range of incidence angles and the first selected range of wavelengths such that the first selective interfering filter medium is operable to inhibit, at a first rejection rate, the transmission of the first selected range of wavelengths of incident light incident on the first zone in the first selected range of angles of incidence.
[0040] It will be understood that the steps of the method may be performed in any suitable order. For example, the unfinished surface can be leveled before or after one of the surfaces is supplied with selective interfering filtration media. Preferably, the unfinished surface is re-rolled prior to supplying selective interfering filtration media.
[0041] In the context of the present invention, the term optical device includes optical lenses that comprise an optical substrate such as ophthalmic lenses, contact lenses, intraocular lenses (IOL), etc. The term also covers other optical devices that have an optical substrate, such as, for example, windows, car and aircraft windshields, films, ophthalmic instrumentation, computer monitors, television displays, telephone screens, multimedia display displays, illuminated signs, light projectors and light sources and the like. In the context of the present invention, "ophthalmic lenses" means corrective and non-corrective lenses and also masks and other vision devices intended to be worn in front of the eyes. Ophthalmic lenses may comprise specific functions, eg solar, anti-reflective, anti-smudge, anti-abrasive.
[0042] Parts of some of the methods according to the invention can be implanted by computer. Such methods can be implemented in software on a programmable device. They can also be deployed in hardware alone or in software or a combination thereof.
[0043] As some embodiments of the present invention may be implemented in software, the present invention may be embodied as computer-readable code for delivery to a programmable apparatus on any suitable carrier medium. A tangible carrier may comprise a storage medium such as a floppy disk, a CD-ROM, a hard disk drive, a magnetic tape device or a solid-state memory device and the like. A transient carrier medium may include a signal such as an electrical signal, an electronic signal, an optical signal, an acoustic signal, a magnetic signal, or an electromagnetic signal, for example, an RF or microwave signal. BRIEF DESCRIPTION OF THE DRAWINGS
[0044] The embodiments of the invention will now be described, by way of example only and with reference to the following drawings, in which:
[0045] Figure 1A is a schematic diagram of an optical device comprising an optical substrate according to a first embodiment of the invention;
[0046] Figure 1B schematically illustrates geometric features of an eye in the context of embodiments of the invention;
[0047] Figures 1C and 1D schematically illustrate geometric parameters related to a line of sight in central vision and peripheral vision, respectively;
[0048] Figures 1E to 1G schematically illustrate the relationship between incident light and lines of sight of a user;
[0049] Figure 2 is a schematic diagram of an optical device comprising an optical substrate according to a second embodiment of the invention;
[0050] Figure 3 is a schematic diagram of an optical device comprising an optical substrate according to a third embodiment of the invention;
[0051] Figure 4 is a schematic diagram of an optical device comprising an optical substrate according to a fourth embodiment of the invention;
[0052] Figure 5 is a schematic diagram of an optical device comprising an optical substrate according to a fifth embodiment of the invention;
[0053] Figures 6A to 6C are schematic diagrams of an optical device comprising an optical substrate according to a sixth embodiment of the invention;
[0054] Figures 7A to 7C are schematic diagrams illustrating examples of lines of sight through an optical lens;
[0055] Figure 8 is a schematic diagram of a progressive ophthalmic lens comprising an optical substrate in accordance with an additional embodiment of the invention;
[0056] Figures 9A to 9C are schematic diagrams illustrating examples of lines of sight through an optical lens for setting a range of incidence angles;
[0057] Figures 10(i) to 10(viii) illustrate, in graphic form, the absorption spectrum of selected dyes and pigments used in selective filters according to some embodiments of the invention;
[0058] Figures 11(i) to 1(viii) illustrate, in graphic form, the absorption spectrum of porphyrins used in selective filters according to some embodiments of the invention;
[0059] Figure 12 illustrates, in graphical form, the transmission spectrum of a dual filter provided by one or more embodiments of the invention;
[0060] Figure 13 illustrates, in graphic form, irradiance applied during in vitro cell exposures for different wavelength ranges indicated by their respective central wavelength;
[0061] Figure 14 illustrates, in graphic form, death of RGC in vitro after exposure to light at different wavelengths; and
[0062] Figures 15A and 15B illustrate, in graphical form, death of RPE cells in vitro by apoptosis after exposure to light at different wavelengths, respectively, in the absence and presence of A2E. DETAILED DESCRIPTION
[0063] As used herein, a filter "selectively inhibits" a range of wavelengths if it inhibits at least some transmission of wavelengths within the range, while having little or no effect on transmission of wavelengths. visible waveform out of range unless specifically configured to do so. The term rejection rate, inhibition rate or degree of inhibition refers to the percentage of incident light in one or more selected wavelength ranges that is avoided to be transmitted. The wavelength parameter range (target range) or bandwidth is defined as the Full Width at Half Maximum (FWHM)
[0064] An optical device according to the first embodiment of the invention will be described with reference to Figure 1A. Figure 1A is a schematic diagram of an optical lens 100 comprising an optical base substrate 110 having a first surface 111 and a second surface 112. In the specific embodiment of an optical lens, the first surface 111 is a concave rear surface disposed, during use, proximate to a user's eye 50 and the second surface 112 is a convex front surface disposed, during use, away from the user's eye 50. Optical lens 100 further comprises a selective interfering filter 120 provided, in that particular embodiment, as a layer, over the front surface 112 of the base optical substrate 110 and shaped to conform to the shape of the front surface 112. In other embodiments, the interfering filter selective can be provided, as a layer, or as part of a layer, on the optical substrate 110.
[0065] The selective interference filter 120 operates as a band-stop filter that selectively inhibits the transmission, through the base optical substrate 110 towards a user's eye 50, of light in a selected range of wavelengths (a range of wavelengths). target wavelength), incident on the front surface 102 of optical lens 100. Selective interference filter 120 is configured to inhibit transmission of light in the target wavelength range, at a given rejection rate, while having little or no effect on the transmission of incident light of wavelengths outside the selected range of wavelengths. In some embodiments, selective interference filter 120 may be configured to inhibit, to some degree, the transmission of incident light of wavelengths outside the target wavelength range, usually through absorption, but at a particular rate of inhibition, which is less than the rejection rate of the wavelengths in the target range.
[0066] A user's eye 50 is made up of a succession of di diopters and includes a pupil P, a center of rotation CRO and a retina. Eye features can be represented through models, such as the Liou & Brennan model, as illustrated in Figure 1B.
[0067] A user's potential sightlines are defined in more detail with reference to Figures 1C and 1D. Referring to Figure 1C for a main line of sight 1 in central vision, light 11 passes through the eye's center of rotation (CRO). The main line of sight 1 from the CRO to an optical substrate 800 is defined by an angle α defined with respect to a vertical plane and an angle β with respect to the XZ (horizontal plane). Referring to Figure 1D for a line of sight 2 in peripheral vision, light 22 passes through the center of the pupil P of the eye. Line of sight 2 in peripheral vision from pupil P to optical substrate 800 is defined by an angle α' defined with respect to a vertical plane and an angle β' with respect to X'Z' (horizontal plane).
[0068] Figure 1E schematically illustrates the relationship between a line of sight 1 and an incidence angle i of a central incident ray 11 on an optical substrate 800. The angle between the normal and posterior surface (the surface close to a user ) S2 of optical substrate 800 and line of sight 1 is referred to as r and the angle between the normal and front surface (the surface far from a user) S1 of optical substrate 800 and incident ray 11 is referred to as i called the central angle of incidence. The relationship between the angles ie (α,β) depends on numerous parameters of the optical substrate such as the lens geometry including the thickness t of the optical substrate 800 and the central prism, as well as the surface equations that define the front and back surfaces S1 S2 of the optical substrate 800 and the refractive index n of the optical substrate. It also depends on the use of the optical substrate, for example on the distance at which objects are being observed.
[0069] Figure 1F schematically illustrates the relationship between a peripheral ray 2 and an incidence angle i' of a peripheral incident ray 22 on an optical substrate 800. The angle between the normal and posterior surface (the surface close to a user ) S2 of optical substrate 800 and peripheral ray 2 is referred to as r' and the angle between the normal and front surface (a user's distant surface) S1 of optical substrate 800 and incident ray 22 is referred to as i' called the peripheral angle of incidence. The relationship between the angles i' and (α',β') depends on numerous parameters of the optical substrate such as the lens geometry including the thickness t of the optical substrate 800 and the central prism, as well as the surface equations that define the surfaces front S1 and rear S2 of the optical substrate 800 and the refractive index n of the optical substrate. It also depends on the use of the optical substrate, for example on the distance of objects under observation.
[0070] It is known that interfering filters have angular sensitivity. For a bandstop filter designed to reject a specific wavelength A at normal incidence, increasing incidence angles imply a spectral shift of the rejected wavelength towards shorter wavelengths, an enlargement of the reject band, and a decrease in the bounce rate. Under usual lighting conditions, a large number of different angles of incidence reach an optical substrate (non-collimated lighting conditions), for example, when the optical substrate is illuminated by sunlight. Considering all incident angles, the transmission spectrum of the filter is significantly modified: the bandwidth of the reject band is significantly increased and the filtering is no longer centered on the wavelength A. For ophthalmic applications, this angular dependence phenomenon can significantly increase the color distortion induced through filtration and can significantly introduce user discomfort.
[0071] Selective interference filter 120 is configured to more satisfactorily control and/or minimize angular sensitivity.
[0072] To better control the spectral response of the band-stop filter, among the large amount of incidence angles that can impact the optical substrate for typical non-collimated light sources, such as sunlight, only those that reach the retinal area to be protected are determined and the filter is numerically designed considering all these angles of incidence instead of being designed considering only one angle of incidence, which is a condition of limited collimated illumination. These angles of incidence form a cone of angles of incidence that depend on several parameters such as the main line of sight, the size of the retina to be protected and the distance between the user and the optical substrate.
[0073] Figure 1G schematically illustrates the determination of the cone of incidence angles associated with the main central line of sight 1M. The cone of angles of incidence is defined by all angles of incidence between i'1 and i'2 which are the angles of incidence of the peripheral rays of light that reach the edges of the retinal area to be protected. This can also be defined by all angles between (dα'1,dβ'1) and (dα'2,dβ'2), where (dα'n,dβ'n) (n = 1,2) correspond to the variation of angles of peripheral rays of light in relation to the main line of sight 1M.
[0074] The optical lens additionally comprises a protective film 130 positioned over the selective interference filter 120 to provide mechanical and environmental protection. Protective film 130 may also be provided with an anti-reflective coating to prevent reflection of incident light across the visible spectrum or in a selected wavelength range of the visible spectrum.
[0075] In general, interfering filters are based on Bragg grids in which s particular wavelengths of light are reflected and other wavelengths are transmitted. This is achieved by adding a periodic variation to the refractive index of a layered structure, which generates a wavelength-specific dielectric mirror. Selective interference filter 120 of embodiments of the invention may be configured to inhibit transmission of incident light through reflection, refraction, or diffraction. For example, the selective interference filter 120 can be manufactured using interference related technologies such as thin film technology, holographic techniques, interference recordings or photonic range gap materials such as liquid crystal technology, including cholesteric crystals.
[0076] In one example, the selective interference filter 120 may comprise a thin film device that has a plurality of layers with different optical refractive indices. In general, thin film technology uses multiple layers that alternate two or more inorganic or hybrid materials with different refractive indices. Each layer may be provided as a coating deposited on the front surface 112 of the base optical substrate 110 by techniques such as sputtering, vacuum evaporation, or physical or chemical vapor position. Such technology is used for anti-reflective coatings on goggles, eyewear, and clear optical surfaces.
[0077] A hybrid inorganic and organic stack of layers can be used to optimize mechanical strength and curvature compatibility. The layers can be deposited on a polymeric film of PET (polyethylene terephthalate), TAC (cellulose triacetate), COC (cyclic olefin copolymer), PU (polyurethane) or PC (polycarbonate) and then laid out on an outer side. of the front surface 112, for example, by a transfer operation on the outside of the front surface. A transfer operation includes a coating or film initially disposed on a first support being transferred cohesively from the first support onto another support; or transferring a self-supporting coating or film directly to a backing. In the present example, the support is the optical substrate.
[0078] The bond between the coating or film and the outer surface of the optical substrate can be achieved through activation of the surface of the coating or film and/or by a means that has the ability to create physical or chemical interactions or through an adhesive (glue).
[0079] In a particular embodiment of the invention, the selective interfering filter thin film technology can be adapted so that many layers are used, for example 20 layers.
[0080] In a further embodiment, the selective interference filter 120 may comprise a Rugate filter device that has a variable optical refractive index, which varies sinusoidally with depth. A Rugate filter allows for reflection function instability outside the selected inhibition range to be minimized.
[0081] The Rugate filter can be applied as a coating to the front surface 112 in a similar manner to the thin film technology as described above.
[0082] In another embodiment, selective interference filter 120 may comprise a holographic device comprising a holographic record. Examples of holographic recording are given in the document “Holographic Imaging” by Stephen A. Benton and V. Michael Bove, Wiley-Interscience, 2008. The recording of holographic band-cut reject filters is typically fabricated by forming in a photosensitive material. the interference of two appropriately shaped coherent laser beams, each propagating in a chosen direction. Controlling the optical elements of the setup, such as the vergence, shape, and relative intensity of each beam, is used to manage the registration step. The exposure and processing of the photosensitive material are monitored in order to obtain the necessary performances to define the target range of wavelengths to be initiated and to ensure the centering of the range in a given wavelength.
[0083] Such holographic recordings can be made on a photosensitive material, typically, but not exclusively, a photopolymer. The photosensitive material is applied as a coating on a flat or curved surface, or molded between two curved surfaces, one of which can be removed after the recording stage; the hologram can be inscribed in the volume of a thick curved photosensitive material, for example, a photorefractive glass formerly shaped as an optical lens like an ophthalmic lens, which, after registration and fixation, shows a very small index modulation according to the interference designed by the optical structure, so that the periodic index modulation generates the target band-cut filter device.
[0084] Another modality involves recording a predistorted rejection filter, such as a predistorted hologram on a photosensitive material deposited on a flat film of PET, TAC, COC, PU or PC and deposition later, for example, by means of a transfer operation, on a curved substrate, for example, a curved surface of an ophthalmic lens.
[0085] Holograms arranged on a curved surface, for example by means of a transfer operation or any other suitable means, may then be covered by another curved surface, or laminated to the same, so as to be sandwiched between two mechanically stabilized curved substrates.
[0086] An example of a process for manufacturing a holographic device by producing a reflection hologram is disclosed in U.S. 4,942,102. An example of tuning a holographic grid is disclosed in U.S. 5,024,909. A variant for continuous recording of a large holographic element is disclosed, for example, in EP 0,316,207 B1.
[0087] In another embodiment, the selective interference filter may comprise a photonic band gap material, such as, for example, cholesteric liquid crystal. The use of cholesteric crystals allows an electrically controllable filter to be devised. In order to obtain a reflection > 50%, two layers can be used. The cholesteric liquid crystals may be provided in the form of at least one sealed layer of liquid or gel on the first surface of the optical substrate.
[0088] Photonic crystals are periodic arrangements of layers of metallic or dielectric objects that may have a range of prohibited wavelengths, the so-called photonic range gap (PBG), analogous to electronic range gaps in semiconductor materials. The geometry of the periodic pattern and the material properties of the substrate determine the photonic band structure, ie, the scattering.
[0089] Photonic crystals can be constructed in a two, or three dimensions. 1D photonic crystals, like the standard Bragg reflector, can be manufactured by successive deposition layers of different dielectric constant. The fabrication of a 1D periodic structure can be achieved by applying as a coating, on a PET, TAC, COC, PU or PC film, alternating layers of different refractive indices in bulk, in which such layers are produced from homogeneous or are constituted by the arrangement of identical geometric structures, for example, sets of identical spheres monodisperse in relation to size or by periodic organization of a PDLC polymer (polymer dispersed liquid crystal) and then arranging on a curved surface of a optical lens, for example, through a transfer operation. Such a 1D periodic structure applied as a coating on a PET, TAC, COC, PU or PC film can be mechanically, thermally, electrically or even chemically activated to induce a controlled modification of the central filtration wavelength and/or bandwidth. filtration, as described in Nature Photonics Volume 1 No. 8 - August: P-Ink Technology: Photonic Crystal Full-Colour Display, by André C. Arsenault, Daniel P. Puzzo, Ian Manners & Geoffrey A. Ozin.
[0090] For 2D photonic crystals, reactive ion etching (J. O'brien, et al., Lasers incorporating 2D photonic bandgap mirrors, Electronics Letter, 32, 2243 (1996); Mei Zhou, Xiaoshuang Chen, Yong Zeng, Jing Xu, Wei Lu, Fabrication of two-dimensional infrared photonic crystals by deep reactive ion etching on Si wafers and their optical properties, Solid State Communications 132, 503 (2004)) or aluminum oxide films (H. Masuda, et al. ., Photonic band gap in anodic porous alumina with extremely high aspect ratio formed in phosphoric acid solution, Japanese Journal of Applied Physics, 39, L1039 (2000)) are common fabrication approaches. PBG em can also be manufactured by interference recording (called “holographic” recording, sometimes followed by reactive ion recording. 3D photonic crystals can be manufactured in a classical layer-by-layer manner (S. Y Lin, et al., A three dimensional photonic crystal operating at infrared wavelength, Nature 394, 251 (1998)). This technique has the advantage of allowing excellent control of the optical structure band gap. They can also be fabricated using alternative techniques, including Lithography X-Ray (LIGA), Holographic Lithography - interference of four non-coplanar laser beams in a light-sensitive polymer generates a three-dimensional periodic structure; two-photon polymerization (TPP), using two-photon absorption with one laser pulsed to stimulate photopolymerization, three-dimensional microfabrication with two-photon absorption photopolymerization.Another technique for the production of photonic crystals uses the self-assembly of and colloidal polymer microspheres in colloidal crystals. For example, colloidal suspensions of opal glass beads are disclosed in the document (S. John, Photonic Bandgap Materials, C. Sokoulis, Ed. Dordrecht: Kulwer Academic Publishers (1996)). Diffraction of Bragg light in colloidal crystals gives rise to a band-cut filter. Another technique consists of inverting an opal, for example, removing (dissolving) the latex spheres in an artificial opal and leaving the surrounding structure. Inverted opadas were within the first 3D PBG manufactured (quote: Voss, Netherlands)
[0091] The photonic crystal periodic structures can be applied as a coating on a PET, TAC, COC, PC or PU film and combinations thereof, or made active, in particular electrically active, in the case of the organization of Scattered Liquid Crystals of Holographic Polymer, the passive or active devices are then arranged on a curved surface of an optical lens, for example, by means of a transfer operation.
[0092] In a particular embodiment, the selective interference filter 120 may be configured as an interference grid device, arranged so that the selected range of angles of incidence are centered at an angle of incidence substantially normal to the interference patterns of the grid. of interference.
[0093] With the use of the different types of interference filter technology described above, inhibition of transmission of a target wavelength range according to user requirements can be achieved.
[0094] In the case, for example, of a selective interfering filter 120, for inhibiting the transmission of phototoxic light in the first selected range of wavelengths, the selective interfering filter 120, based on one or more of the technologies described above, can be configured to inhibit the transmission of light incident on the front surface of the optical device 100 wavelengths in a bandwidth in a range of 10 nm to 70 nm, preferably 10 nm to 60 nm centered on a wavelength in a range between 430 nm and 465 nm while allowing the transmission of incident light outside the target wavelength range. Since this target wavelength range corresponds to the wavelength range of toxic light (as described in the following and shown in Figures 14 and 15), protection of the resin against such light can be achieved.
[0095] Furthermore, the selective interfering filter may be configured to transmit specific wavelengths of toxic light for certain eye disorders or disease.
[0096] For example, glaucoma is an eye disorder in which the optic nerve is damaged, inflicting permanent impact on the vision of the affected eye(s) and progressing to total blindness if left untreated. Furthermore, nerve damage involves the loss of retinal ganglion cells in a characteristic pattern. Worldwide, it is the second leading cause of blindness. Glaucoma is often, but not always, associated with increased fluid pressure in the anterior segment of the eye (aqueous humor).
[0097] Several studies have been conducted relating to the possible causes of glaucoma. However, even if there is increasing evidence that ocular blood flow is involved in the pathogenesis of glaucoma and a possible correlation between hypertension and the development of glaucoma is shown, experiments are still carried out. Intraocular pressure is only one of the main risk factors for glaucoma, however, lowering it with various pharmaceuticals and/or surgical techniques is currently the main line of glaucoma treatment. For now, managing glaucoma requires proper diagnostic techniques and follow-up examination, as well as judicious selection of treatments for the individual patient. In particular, intraocular pressure can be reduced with medication, usually eye drops. However, treatment does not always stop the degenerative process even if intraocular pressure is reduced to a normal level. Laser surgery and conventional surgery are performed to treat glaucoma. Surgeries are the primary therapy for those suffering from congenital glaucoma.
[0098] Retinopathy is the general term referring to some forms of non-inflammatory damage to the retina of the eye. Often, retinopathy is an ocular manifestation of systemic disease. Diabetic retinopathy is caused by complications of diabetes mellitus, which can eventually lead to blindness. It is an ocular manifestation of a systemic disease that affects up to 80% of patients who have had diabetes for ten years or more. Diabetic retinopathy is associated with microvascular retinal changes. Retinal ganglion cells were recently found to degenerate during diabetic retinopathy (http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2008.156695/full; and Kern TS and Barber AJ Retinal Ganglion Cells in Diabetes. The Journal of Physiology 2008. Wiley online library)
[0099] Retinal ganglion cell death has been observed in some other pathologies where mitochondrial function is disrupted such as Leber's hereditary optic neuropathy.
[00100] Inventive studies were carried out by the inventors on the influence of light on retinal ganglion cell (RGC) dysfunction and its associated pathologies such as glaucoma, diabetic retinopathy and Leber's optic neuropathy,
[00101] Phototoxicity in RGC was performed using a primary cell model of glaucoma. Studies have shown that purified adult mouse retinal ganglion cells are a suitable in vitro model of glaucoma (Fuchs C et al, IOVS, Retinal-cell-conditioned medium prevents TNF-alpha-induced apoptosis of purified ganglionic cells. 2005). Therefore, to determine whether light-induced cell death may contribute to the degeneration of such cells in glaucoma, diabetic retinopathy, and Leber's hereditary optic neuropathy, primary cultures of adult rat retinal ganglion cells were exposed to light for 15 hours in 96-well culture with clear black background. Light exposures were selected from 385 to 525 nm in 10 nm increments and designated by the central wavelength as illustrated in Figure 13. To avoid any light filtering effect from the medium, cells were cultured in an NBA medium without aromatic amino acids, Phenol red or whey and other photosensitive molecules in the visible spectrum. Light irradiance was normalized with respect to natural sunlight (solar reference spectrum ASTM G173-03) reaching the retina after filtration through ocular optics (cornea, lens and vitreous humor EA Boettner, Spectral Transmission of the Eye, ClearingHouse, 1967). For these neuronal cells, cell viability was assessed with the highly sensitive CellTiter-Glo viability assay (Promega, Madison, Wisconsin, USA). Figure 14 illustrates RGC survival for all light exposures tested thus indicating corresponding cell loss relative to the control condition. Experimental data indicated that retinal ganglion cell loss was induced with all 10 nm bandwidths from 420 to 510 nm show the most satisfactory effects with bandwidths centered at 450, 460 nm and 470 nm.
[00102] Thus, in a particular embodiment, the target band may have a bandwidth of 10 nm to 70 nm, preferably 15 to 25 nm, centered on a wavelength of about 460 nm. It has been shown by the cellular model studies of RGC performed by the inventors as described above that this target band is particularly toxic to individuals with glaucoma, diabetic retinopathy or Leber's hereditary optic neuropathy. Consequently, preventing transmission of wavelengths in this target range to a user's eye provides protection and reduces the progress of these particular diseases.
[00103] Inventive studies were also carried out by the inventors on the influence of light on the retinal pigment epithelium (RPE) and the associated pathologies such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa or Best's disease.
[00104] The RPE of patients affected by AMD was found to contain increased concentrations of A2E (CA.Parish et al., Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium, IOVS, 1998) . Therefore, to generate a model of AMD, retinal pigment epithelium cells isolated from swine eyes were incubated in the presence of A2E (40 μM) for 6 hours to trigger its cellular uptake. After a medium change, these primary cell cultures of RPE cells were exposed to 10 nm bandwidth light in black clear-bottomed 96-well culture plates for 18 hours. Light exposures were selected from 385 to 525 nm in 10 nm increments and designated by the center wavelength as illustrated in Figure 13 (eg 390 nm for the 385 to 395 nm bandwidth). To avoid any light filtering and/or photosensitization of the culture medium, cells were cultured in a DMEM medium lacking aromatic amino acids, Phenol Red or serum and other photosensitive molecules. Light irradiance was normalized with respect to natural sunlight (solar reference spectrum ASTM G173-03) reaching the retina after filtration through ocular optics (cornea, lens; EA Boettner, Spectral transmission of the eye, ClearingHouse, 1967) . RPE cell apoptosis was quantified 6 hours after illumination. Figure 15A illustrates the absence of light-induced apoptosis in the absence of A2E incubation as measured with Apotox-Glo by caspase-3 activation reported by cell viability (Promega, Madison, Wisconsin, USA). In contrast, Figure 15B shows that when A2E was pre-incubated with RPE cells, RPE apoptosis was induced significantly with the 10 nm bandwidths centered at 420, 430, 440 and 450 nm (from 415 to 455 nm).
[00105] So, in another example, the target band can have a bandwidth of 10 nm to 70 nm, preferably 15 to 25 nm, centered on a wavelength of about 435 nm. It has been shown, by the inventive studies described above, that such a target range is particularly toxic for individuals with AMD, Stargardt's disease, retinitis pigmentosa or Best's disease and, therefore, the prevention of transmission of wavelengths in this target range to the A wearer's eye provides protection and reduces disease progress.
[00106] In another example, the target band may have a bandwidth of 30 to 70 nm, preferably 30 to 60 nm centered on a wavelength of about 445 nm. It has been shown, by the inventive studies on the cellular models of RGC described above, that such a target range includes those wavelengths that were particularly toxic to individuals with glaucoma, diabetic retinopathy or Leber optic neuropathy, as was shown by the studies cell model of RPE, that the wavelengths were particularly toxic to individuals with AMD, Stargardt's disease, retinitis pigmentosa, or Best's disease, and thus preventing transmission of wavelengths in that target range to the eye of a user provides protection and slows the progress of any one, or several, of these diseases.
[00107] In the case, for example, of preventing melatonin suppression, the selective interference filter 120, based on one or more of the technologies described above, may be configured to inhibit the transmission of light wavelengths in a target range from 465 nm to 495 nm centered on a wavelength of 480 nm, for example. Light that has wavelengths in this wavelength range suppresses melatonin production. Melatonin (N-acetyl-5-methoxytryptamine) is the main hormone of the pineal gland and controls many biological functions, particularly the timing of these physiological functions which are controlled by the duration of light and dark. In this way, optical devices that have selective filtration media configured to inhibit light transmission in this target wavelength range can be used to prevent melatonin suppression, particularly at night.
[00108] In the case, for example, of compensation and contrast restoration on the red-green geometry axis for enhanced color vision, the selective interference filter 120 can be configured to inhibit the transmission of light wavelengths over a range of lengths. target waveform from 550 nm to 660 nm, for example.
[00109] In the case, for example, of treating or preventing migraine, the selective interference filter 120 can be configured to inhibit the transmission of light wavelengths in a target wavelength range of 590 nm to 650 nm, for example example, and preferably 615 to 625 nm.
[00110] In the case, for example, of treating epilepsy or preventing epileptic seizures, the selective interference filter 120 can be configured to inhibit the transmission of light wavelengths in a target wavelength range from 560 to 600 nm .
[00111] In a particular embodiment, selective interference filter 120 may be configured to inhibit transmission of wavelengths in two target wavelength ranges. The specific configuration of the selective interference filter to provide narrow band widths allows dual band selective interference filters to be used. The dual band selective interference filter can be provided through the use of two different interference filters that inhibit transmission in different target wavelength ranges or through a single interference filter configured to inhibit transmission in two different target wavelength ranges. wavelengths.
[00112] One embodiment of providing a dual band filter may involve recording, simultaneously or consecutively, two holograms on the same photosensitive material to produce two different target wavelength filtration bands, each target wavelength band can be characterized by its own bandwidth, center wavelength and own rejection factor.
[00113] In another embodiment, two holograms, each coated in a PET, TAC, COC, PC or PU film or glass and recorded in the same type of photosensitive material or in two different photosensitive materials are stacked one on top of the other , together with their substrate or after they have been lifted from their substrate, in particular, to be deposited or thermoformed on a curved substrate.
[00114] In one of the possible deployments, a mixture of two technologies can be used to produce a dual band filter, for example a hologram can be superimposed on an absorption filter made of a layer that contains a pigment or a dye, for example, a pigment or dye of embodiments that will be described later in the present application.
[00115] In another embodiment, the mixture of two technologies is composed of the superposition of two selective filters generated with two different absorption layers, each one containing its appropriate pigment or dye, regardless of the order of the two layers;
[00116] In another embodiment, a hologram is stacked with a 1D or 2D photonic crystal or a stack of thin films, regardless of the substrate on which they were prepared or lifted and regardless of the order of superimposition.
[00117] In another embodiment, a thin film stack is superimposed on a photonic crystal, regardless of the order of the superimposition being unimportant and the optically transparent substrate on which the two selective filters were deposited.
[00118] In this way, two or more target wavelengths at which incident light transmission is initiated can be obtained. For example, a first wavelength target band may have a bandwidth of 10 to 30 nm, preferably 5 to 25 nm centered on a wavelength of about 435 nm and a second wavelength target band may have a bandwidth of 10 to 30 nm, preferably 15 to 25 nm centered on a wavelength of 460 nm. As in the previous example, the target wavelength range includes those wavelengths that have been shown by RGC cell model studies performed by the inventors to be particularly toxic to individuals with glaucoma, diabetic retinopathy, or Leber's hereditary optic neuropathy as well as those wavelengths that have been shown by RPE cell model studies to be particularly toxic to individuals with AMD, Stargardt's disease, retinitis pigmentosa, or Best's disease. However, the interfering filter 120 in this particular example is more selective and allows for increased light transmission between the two target bands thereby having a reduced effect of visual color distortion and improved scotopic vision.
[00119] The rejection rate in the one or more target wavelength ranges can be adjusted by setting the selective interference filter 120 using the appropriate different technology described above according to the needs of users. For example, for general protection use, the rejection rate within the single target wavelength range or dual target wavelength ranges may be set to 30-50% in order to limit color perception distortion. , disturbance of scotopic vision and disturbance of non-visual functions of the eye. To slow the progress of diseases such as AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, glaucoma, diabetic retinopathy or Leber's hereditary optic neuropathy, the rejection rate can be increased to about 80 to 100% in order to provide Enhanced protection for a diseased eye. For use that requires sun protection, for example, transmission over the entire visible spectrum is initiated at an inhibition rate in the range of 40% to 92% and the first rejection rate can be set to provide at least 5% additional inhibition for the first selected range of wavelengths.
[00120] An optical device according to the second embodiment of the invention will be described with reference to Figure 2. Figure 2 is a schematic diagram of an optical lens 200 comprising an optical base substrate 210 having a first surface 211 and a second surface 212 similar to the base optical substrate of the first embodiment. Optical lens 200 further comprises a selective interference filter 220 provided on the front surface 212 of base optical substrate 210. Selective interference filter 220 operates in the same manner as selective interference filter 120 of the first embodiment. The second embodiment differs from the first embodiment in that the back surface 211 of the optical substrate is provided with a layer of absorbing material 222 configured to absorb a portion of the light in the target bandwidth of the selective interfering filter 220. First, this significantly reduces the parasitic light reaching the user's eye, which comes from the light incident on the back surface 201 of the optical device and reflected by the selective interfering filter 220. In fact, the presence of the selective interfering filter 220 introduces the reflection of parasitic light back to the eye and thus the presence of the absorbing material layer 222 helps to lessen unwanted reflection effects. Thereafter, the absorbing material 222 enhances the spectral filtration introduced by the selective interfering filter 220 since some light at the target wavelength that was not rejected by the selective interfering filter 220 can then be attenuated by the absorbing material layer 222.
[00121] In other embodiments, a layer of absorbing material 222 is configured to absorb light in a target wavelength range different from the target wavelength range of the selective interfering filter 220, which helps to provide a balancing effect of color. For example, some absorption in the region of the red-orange part of the visible spectrum helps to attenuate the color perception distortion induced by the selective interfering filter 220. In additional embodiments, the use of a layer of absorbing material 222 that operates to absorb light in a target wavelength range different from the target wavelength range of the selective interference filter 220 as well as in the same target wavelength range can be used to provide a color balance effect as well as an enhanced filtering effect.
[00122] In some embodiments, a layer of non-selective absorbing material that operates to absorb light in the full range of the visible spectrum may be used.
[00123] The absorbent material may be an absorbent dye or pigment as will be described in later embodiments of the present invention.
[00124] Although in this embodiment the absorbing layer is provided on the back surface of the optical substrate, it will be appreciated that in other embodiments of the invention, the absorbing layer may be provided as a layer within the optical substrate, between the selective interfering filter and the back surface of the optical substrate.
[00125] An optical device according to the third embodiment of the invention will be described with reference to Figure 3. Figure 3 is a schematic diagram of an optical lens 300 comprising an optical base substrate 310 having a first surface 311 and a second surface 312 similar to the base optical substrate of the first embodiment. Optical lens 300 further comprises a first selective interference filter 320 provided on the front surface 312 of base optical substrate 310 and a second selective interference filter 322 provided as a layer within the volume of base optical substrate 310. Selective interference filters 320 and 322 operate in the same manner as the selective interference filter 120 of the first embodiment. Both the first selective interference filter 320 and the second interference filter 322 may be configured to inhibit transmission in the same target wavelength range. The advantage provided by this embodiment is that the second interfering filter 322 can provide enhanced protection in the target wavelength range by allowing a general increase in rejection factor in the target wavelength range to be achieved. This enhanced protection can be tailored to the needs of the wearer, thereby providing design flexibility, for example depending on whether or not the wearer suffers from a disease such as AMD, Stargardt's disease, retinitis pigmentosa, Best, glaucoma, diabetic retinopathy or Leber's hereditary optic neuropathy or to what degree the user suffers from that disease. For example, a first selective interfering filter 322 on the optical substrate can provide a level of protection for normal use while the addition of a second selective interfering filter 320 on the front surface of the optical substrate can increase that level of protection to a therapeutically adequate level to prevent the progress of disease in an individual susceptible to or suffering from any of the aforementioned diseases.
[00126] The back surface 311 of the optical substrate may be provided with a layer of absorbing material 324, similar to the layer of absorbing material of the second embodiment, configured to absorb light at the target bandwidth of the selective interfering filter 322 and/or the selective interfering filter 320. Providing the absorbing material 324 in this way significantly reduces parasitic light reaching the user's eye, which comes from light incident on the back surface 311 of the optical device and reflected by the selective interfering filter 322 and/or interfering filter. selective 320. In addition, the absorbing material 324 enhances the spectral filtration introduced by the selective interference filter 322 and/or selective interference filter 320.
[00127] Like the absorbing material layer of the previous embodiment, the absorbing layer 324 can also be configured to absorb light in a different wavelength range than the target bandwidth of the selective interference filter 322 and/or the selective interference filter 320 for color balance or in the full range of the visible spectrum or in the target bandwidth of the selective interference filter 322 and/or the selective interference filter 320 for enhanced protection and the different wavelength range for color balance.
[00128] In additional embodiments, one of the selective interfering filters may be added to the front surface of the optical substrate to provide protection in a target wavelength range different from the target wavelength range of a selective interfering filter provided within the optical substrate or on the front surface of the optical substrate. By adding protection within a different wavelength range, additional uses or protections can be contemplated. For example, in one embodiment, color balance can be provided. In another embodiment, protection in a target wavelength range from harmful light for glaucoma, diabetic retinopathy or Leber's optic neuropathy can be provided by a selective interfering filter and additional protection in an additional target range from light harmful to AMD, Stargardt's disease, retinitis pigmentosa or Best's disease can be provided by another selective interfering filter. Alternatively, one selective interfering filter may be configured to protect against a range of wavelengths in one part of the electromagnetic spectrum while the other selective filter may be configured to protect against a range of wavelengths in another part of the electromagnetic spectrum.
[00129] An optical device according to the fourth embodiment of the invention will be described with reference to Figure 4. Figure 4 is a schematic diagram of an optical lens 400 comprising an optical base substrate 410 having a first surface 411 and a second surface 412. In the specific embodiment of an optical lens, first surface 411 is a concave rear/back surface disposed proximate an eye 50 of a wearer in use and second surface 412 is a convex front/front surface disposed in distant use of the user's eye 50. The optical lens further comprises an absorption filter 420 provided, in this embodiment, within the volume of the base optical substrate 410. The absorption filter 420 in this embodiment is provided as a film that contains a dye or pigment and sandwiched between two layers of the optical substrate. base 410. In other embodiments of the invention, the absorbent layer may be provided on the surface of the optical substrate.
[00130] The absorption filter 420 operates as a band-stop filter that selectively inhibits the transmission, through the base optical substrate 410 from the front surface 412 towards a user's eye 50, of light in a selected range of lengths. wavelength, called the target wavelength range, incident on the front surface of the optical lens 100 while having little or no effect on the transmission of incident light of wavelengths outside the selected range of wavelengths, unless specifically configured to do the same. Absorption filter 420 is configured to inhibit transmission of the selected range of wavelengths at a given rate of inhibition. In some embodiments, the optical device additionally comprises a protective film (not shown) positioned over the base optical substrate 410 to provide mechanical and environmental protection. The protective film may also be provided with an anti-reflective coating to prevent reflection of incident light across the visible spectrum or within a selected range of the visible spectrum corresponding, or not, to the target wavelength range of the absorption filter 420.
[00131] Absorbent filter 420 may, in an example of the invention, comprise a dye or pigment such as Auramine O; Coumarin 343; Coumarin 314; proflavine; Nitrobenzoxadiazole; yellow Lucifer CH; 9.10 Bis(phenylethynyl)anthracene; Chlorophyll a; Chlorophyll b; 4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; and 2-[4-(dimethylamino)styryl]-1-methypyridinium iodide, Lutein, Zeaxanthin beta-carotene or lycopene; or any combination thereof. Lutein (also known as Xanthophyll) and Zeaxanthin, for example, are natural protectors that accumulate in the retina, their concentration decreasing with age. Providing an absorption filter that contains such a substance helps to compensate for the natural loss of substances in the eye.
[00132] The choice of pigment or dye will depend on the target wavelength range or 420 absorption filter ranges.
[00133] For example, for protection against phototoxic blue light, numerous dyes or pigments provide a high level of absorption in the wavelength range of 420 nm to 470 nm as illustrated in Figure 10. Figures 10(i) to 10( viii) illustrate the absorption spectra of the following substances respectively (i) Auramine O dissolved in water exhibits an absorption peak at about 431 nm with a bandwidth (measured as FWHM) of 59 nm; (ii) Coumarin 343; dissolved in ethanol exhibits an absorption peak at about 445 nm with a bandwidth (measured as FWHM) of 81 nm; (iii) Nitrobenzoxadiazole dissolved in ethanol; exhibits an absorption peak at about 461 nm with a bandwidth (measured as FWHM) of 70 nm; (iv) yellow Lucifer CH dissolved in water exhibits an absorption peak at about 426 nm with a bandwidth (measured as FWHM) of 74 nm; (v) 9.10 Bis(phenylethynyl)anthracene dissolved in Cyclohexane exhibits an absorption peak at about 451 nm with a bandwidth (measured as FWHM) of 67 nm; (vi) Chlorophyll a dissolved in diethyl ether exhibits an absorption peak at about 428 nm with a bandwidth (measured as FWHM) of 44 nm; (vii) Chlorophyll a dissolved in methanol exhibits an absorption peak at about 418 nm with a bandwidth (measured as FWHM) of 42 nm; (viii) Chlorophyll b dissolved in diethyl ether exhibits an absorption peak at about 436 nm with a bandwidth (measured as FWHM) of 25 nm.
[00134] As can be seen from the respective absorption spectra, these substances provide spectra that have absorption in a narrow bandwidth of FWHM from 10 to 82 nm, thereby providing the means of selective filtration that leads to a reduction in unwanted visual distortion.
[00135] In other embodiments, the absorption filter 420 may contain porphyrins or a derivative thereof.
[00136] Some examples of porphyrins include 5,10,15,20-tetracys(4-sulfonatephenyl) sodium salt porphyrin complex; 5,10,15,20-Tetracis(N-alkyl-4-pyridyl) porphyrin complex; 5,10,15,20-Tetracis(N-alkyl-3-pyridyl) porphyrin metal complex, and 5,10,15,20-Tetracis(N-alkyl-2-pyridyl) porphyrin complex, or any combination of the same. The alkyl may be methyl, ethyl, butyl and/or propyl. All these porphyrins show very good water solubility and are stable up to 300°C.
[00137] The complex may be a metal complex in which the metal may be Cr(III), Ag(II), In(III), Mg(II), Mn(III), Sn(IV), Fe( III) or Zn(II). Such metal complexes exhibit an absorption in water between 425 and 448 nm which corresponds to a range of wavelengths that exhibit phototoxicity. Metal complexes based on Cr(III), Ag(II), In(III), Mn(III), Sn(IV), Fe(III) or Zn(II) in particular have the advantage of not being sensitive to acid and provide more stable complexes, as they will not lose the metal at pH < 6. Furthermore, these porphyrins do not fluoresce at room temperature. Such properties are of interest for use in optical lenses such as ophthalmic lenses, contact lenses and IOLs, for example. Porphyrin can be selected according to the target wavelength range or target wavelength ranges in which light transmission is to be initiated. The wavelength absorption range depends on the solvent and pH. Bandwidth will depend on solvent, pH and concentration, as dyes tend to aggregate at higher concentrations leading to wider peaks. The target range can thus be obtained by choosing porphyrin, pH and solvent, as well as concentration.
[00138] Figures 11(i) to 11(viii) illustrate the absorption spectra of the following porphyrins respectively (i) diprotonated tetraphenylporphyrin dissolved in chloroform and HCl which has an absorption peak at approximately 445 nm with a bandwidth (measured as FWHM) of 18 nm; (ii) Magnesium octaethylporphyrin dissolved in toluene which has an absorption peak of 410 nm with a bandwidth (measured as FWHM) of 14 nm; (iii) Magnesium tetramesitylporphyrin dissolved in toluene which has an absorption peak at 427 nm, with a bandwidth (measured as FWHM) of 10 nm; (iv) Tetracis (2,6-dichlorophenyl) porphyrin dissolved in toluene which has an absorption peak at 419 nm with a bandwidth (measured as FWHM) of 12 nm; (v) porphyrin (o-aminophenyl) Tetracis dissolved in toluene which has an absorption peak at 420 nm with a bandwidth (measured as FWHM) of 30 nm; (vi) Tetramesitylporphyrin dissolved in toluene which has an absorption peak at 427 nm with a bandwidth (measured as FWHM) of 1 nm; (vii) Zinc tetramesitylporphyrin dissolved in toluene which has an absorption peak at 420 nm with a bandwidth (measured as FWHM) of 12 nm; (viii) zinc tetraphenylporphyrin, dissolved in toluene which has an absorption peak at 423 nm with a bandwidth (measured as FWHM) of 14 nm. As can be seen from the respective absorption spectra, these substances provide spectra that have absorption in a narrow FWHM bandwidth of 10 to 30 nm, thereby providing selective absorption filters. The selective enhancement provided by the use of such substances leads to a better reduction in undesirable visual distortion once a more selective target range can be initiated. According to the target range of wavelengths to be initiated, the appropriate porphyrin can be selected.
[00139] Some porphyrins have a particular example of being water soluble such as tetrasodium porphine salt Mg(II) meso-Tetra(4-sulfonatephenyl) has a water absorption wavelength of approximately 428 nm.
[00140] Porphyrins can be selected according to the intended use of the optical device. For example, the following porphyrins give absorption peaks around 460 nm: manganese(III) chloride tetracis(methochloride) 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine exhibits a peak absorption at 462 nm; manganese(III) chloride 5,10,15,20-tetracys(4-sulfonatephenyl)-21H,23H-porphine exhibits an absorption peak at 466 nm, manganese(III) chloride 2,3,7,8,12 ,13,17,18-Octaethyl-21H,23H-porphine exhibits an absorption peak at 459 nm. The use of such substances can be useful, therefore, in inhibiting the transmission of light at a wavelength of 460 nm. Such a wavelength has been shown to be detrimental to RGC in an in vitro model of glaucoma.
[00141] Tetracis(methochloride) zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine exhibits an absorption peak at 435 nm. The use of such substances can be useful, therefore, in inhibiting the transmission of light at a wavelength of 435 nm. Such a wavelength has been shown to be detrimental to RPE in an in vitro model of AMD.
[00142] Other applications or wavelength protection can be contemplated with other porphyrins: 5,10,15,20-Tetracis(4-methoxyphenyl)-21H,23H- porphine cobalt(II) exhibits a first absorption peak at 417 nm and a second absorption peak at 530 nm. Such porphyrin can be used as a dual band absorption filter to filter out wavelengths in the region of both these absorption peaks or used to filter wavelengths for the absorption peaks. Similarly, 5,10,15,20-Tetracis(4-methoxyphenyl)-21H,23H-porphine exhibits a first absorption peak at 424 nm and a second absorption peak at 653 nm.
[00143] Iron(III) chloride 5,10,15,20-Tetracis(4-methoxyphenyl)-21H,23H-porphine exhibits an absorption peak at 421 nm. Zinc tetracyl(methochloride) 5,10,15,20-tetra(4-pyridyl)-21H, 23H-porphine exhibits an absorption peak at 423 nm.
[00144] 5,10,15,20-Tetracis(1-methyl-4-pyridinium) porphyrin tetra(p-toluenesulfonate) exhibits an absorption peak at 421 nm. 5,10,15,20-Tetracis(4-hydroxyphenyl)-21H,23H-porphine exhibits an absorption peak at 421 nm. Tetracis(benzoic acid) 4,4',4,4'''-(Porphine-5,10,15,20-tetrayl) exhibits an absorption peak at 411 nm.
[00145] In additional embodiments, other dyes or pigments that include porphyrins may be selected according to the intended use of the optical device. In the case, for example, of preventing melatonin suppression, one or more dyes or pigments that have an absorption peak in a target range of 465 nm to 495 nm can be selected. Light that has wavelengths in this range suppresses the production of Melatonin. Melatonin (N-acetyl-5-methoxytryptamine) is the main hormone of the pineal gland and controls many biological functions, particularly the timing of these physiological functions which are controlled by the duration of light and dark. In this way, optical devices that have selective filtration media configured to inhibit light transmission in this target range can be used to prevent melatonin suppression, particularly at night.
[00146] 4-(Dicyanomethylene)2-methyl-6-(4-dimethylaminostyryl)-4H-pyran exhibits an absorption peak at 468 nm. 2-[4-(Dimethylamino)stirl]-1-methylpyridinium iodide exhibits an absorption peak at 466 nm.
[00147] 3,3'-Diethyloxacarbocyanine iodide exhibits an absorption peak at 483 nm.
[00148] In the case, for example, of compensation and contrast restoration on the red-green geometric axis, one or more pigments or dyes including porphyrins that have an absorption peak in a target range of 550 nm to 660 nm, for example, can be selected to inhibit light transmission in this target range.
[00149] In the case, for example, of treating or preventing migraine, one or more pigments or dyes, including porphyrins that have an absorption peak in a target range of 590 nm to 650 nm, e.g. preferably 615 to 625 nm to inhibit light transmission in this target range.
[00150] In the case, for example, of treating epilepsy or preventing epileptic seizures, the selective interference filter 120 can be configured to inhibit the transmission of light wavelengths in a target range of 560 to 600 nm.
[00151] The fourth modality absorption filter may be configured as a dual band filter that inhibits the transmission of incident light, through the base optical substrate towards a user's eye 50, of light in two target bands of wavelengths. wave, incident on the front surface 112 of the optical lens 100 while having minimal effect on transmitting incident light of wavelengths outside the two selected wavelength ranges. As illustrated in Figure 12, a dual band filter can be provided that exhibits a low level of transmission within a first range of wavelengths, e.g. centered around 435 nm as illustrated in the example, and a second low level of transmission in a higher range, for example centered around 460 nm while allowing transmission at a high level of light transmittance at wavelengths between the two target ranges.
[00152] So the absorption bandwidths of the substances described above are narrow enough to allow such dual band filters to be provided. The same can be provided through the use of two different substances that exhibit different absorption peaks or by a single substance that has two or more different absorption peaks. Furthermore, a selective interference filter of any of the foregoing embodiments can be combined with an absorption filter of any of the above embodiments to provide a dual band filter. The advantages of having two distinct narrow bands instead of two bands that come together are that color vision distortion and scotopic vision disturbance can be minimized.
[00153] An optical device according to the fifth embodiment of the invention will be described with reference to Figure 5. Figure 5 is a schematic diagram of an optical lens 500 comprising an optical base substrate 510 having a first surface 511 and a second surface 512 similar to the base optical substrate of the first embodiment. Optical lens 500 further comprises a selective interference filter 522 provided on the front surface 512 of the base optical substrate 510 and an absorption filter 520 on the back surface 511 of the base optical substrate. In alternative embodiments, the absorption filter 520 may be included in the volume of the base optical substrate 510, for example, incorporated into the base optical substrate 510 itself. The selective interference filter 521 operates in the same manner as the selective interference filter 120 of the first embodiment and absorption filter 520 operates similarly to the absorption filter of the second embodiment. Both the selective interference filter 522 and the absorption filter 520 can be configured to inhibit a transmission of light in the same target wavelength range. The advantage provided by this embodiment is that the selective interference filter 522 can be added to the optical substrate to provide enhanced protection in the target wavelength range allowing an overall increase in rejection factor at the target wavelength to be obtained. This enhanced protection can be tailored to the user's needs, i.e. depending on whether or not the user suffers from a disease such as AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, Glaucoma, diabetic retinopathy or optic neuropathy of Leber or to what degree the user suffers from that disease. For example, a first filter may provide a level of protection for normal preventive use while the addition of a second filter may increase the level of protection to a therapeutic level for an individual suffering from the disease.
[00154] In an alternative embodiment, the optical substrate can be provided with two absorption filters. At least one of the absorption filters may be added to the surface of the optical substrate to provide enhanced protection in the same target wavelength range as an absorption filter provided on the other surface of the optical substrate or as a layer within the optical substrate. In additional embodiments, one of the absorption filters may be added to the surface of the optical substrate to provide protection in a different target wavelength range than an absorption filter provided on the other surface of the optical substrate or as a layer within the optical substrate. For example, a target range protection from light harmful to glaucoma, diabetic retinopathy or Leber's optic neuropathy may be provided by an absorption filter and additional protection at an additional target range from light harmful to AMD, disease Stargardt's disease, retinitis pigmentosa or Best's disease can be provided by another absorption filter. Alternatively, using filters with different target ranges can allow color balance effects to be achieved.
[00155] Optical substrate-specific interfering filter zones (i.e., optical substrate zones provided with selective interfering filters) of an optical device in accordance with embodiments of the invention can be defined in order to minimize the angular sensitivity of interfering filters and/or to significantly reduce color distortion and light intensity attenuation in certain regions of the optical substrate. This is particularly important in the case where a selective interference filter is applied to an optical lens such as an ophthalmic lens, a contact lens, or an IOL. In the context of the present invention, "ophthalmic lenses" means corrective and non-corrective lenses and also masks and other vision devices intended to be worn in front of the eyes. Ophthalmic lenses can provide specific functions, e.g. solar, anti-reflective, anti-smudge, anti-abrasive, etc.
[00156] In some embodiments of the invention, the optical substrate can be provided with multiple filtering zones, for example in the case of monofocal ophthalmic lenses in the form of concentric circular zones from the center of the optical substrate to the periphery of the optical substrate. Furthermore, the bounce rate may differ from zone to zone.
[00157] An optical device according to the sixth embodiment of the invention will be described with reference to Figures 6A and 6B. Figure 6A is a schematic diagram of an optical lens 600 comprising an optical base substrate 610 having a first surface 611 and a second surface 612. In the specific embodiment of an optical lens, the first surface 611 is a concave rear surface arranged proximate an eye 50 of a user in use and the second surface 612 is a convex front surface disposed in use distant from the eye 50 of the user. Front surface 612 has n number of filtering zones 612-1...612-n (wherein, in that embodiment n=4). Each filtration zone is equipped with a respective selective interference filter 620-1620-n. Each selective interference filter 620-1620-n operates as a band-stop filter that selectively inhibits the transmission, through the base optical substrate 610 towards a user's eye 50, of light in a target wavelength range incident on the front surface 612 of the optical lens within the respective zones 612-1...612-n while having little or no effect on the transmission of incident light of wavelengths outside the target wavelength range. Each selective interference filter 620-1620-n is configured to inhibit transmission of the selected target wavelength if incident light is incident on the respective filtering zone 612_1 -612_n within a respective selected range of angles defined by a cone of angles. Furthermore, each selective interference filter 620-1620-n is configured to inhibit transmission of the target wavelength range at a respective rejection rate. The optical device may additionally comprise a protective film (not shown) positioned over selective interference filters 620-1620-n to provide mechanical and environmental protection. Protective Film 630 may also be provided with an anti-reflective coating to prevent reflection of incident light across the visible spectrum or within a selected range of the visible spectrum. In that embodiment, particularly adapted for monofocal ophthalmic lenses, a central filtration zone 612_1 is provided in the form of a circle while surrounding filtration zones 612_2 to 612_4 are provided as concentric annular rings surrounding the central zone 612_1 as illustrated in Figure 6B.
[00158] In the example of Figure 6B, each of the selective interference filters 620-1620-n is configured so that the respective selected range of angles of incidence is centered at a substantially normal angle of incidence with respect to the interference patterns of the grid 620-1620-n selective interference filter. The interference patterns of the respective surrounding selective interference filters 620-2620-n are skewed with respect to the interference patterns of the interference grid of the central selective interference filter 620_1 based on the position of the respective surrounding area 612_2, 612_3, 612.4 relative to to the central zone 612_1. that is, the angle of inclination of the interference patterns of the selective interference filters 620_1 to 620_4 increases as illustrated in Figure 6B from the central zone towards the peripheral zone of the optical substrate. This means that each selective interference filter 612_1 to 612_4 can be configured to operate in the target wavelength range for different ranges of incidence angles.
[00159] The 620_1 Selective Interfering Filter provided for the 612_1 Center Filtration Zone may be configured to have a higher reject rate than the other Selective Interfering Filters 620_2 through 620_4. The rejection rate of the other selective interference filters 620_2 to 620_4 can be configured so that the rejection rate decreases from the central zone to the peripheral zone as illustrated in Figure 6C. A filtration gradient from the center to the periphery of the optical substrate can thus be provided.
[00160] The design of an optical substrate with multiple filtration zones as described above minimizes the angular sensitivity of the band-stop filter as illustrated in Figure 6C.
[00161] Each filtering zone of the optical substrate is preferably associated with at least one line of sight and an associated incident angle cone. In particular, a spatially central zone of the lens generally corresponds to the primary contemplation direction (line of sight when the wearer is looking straight into infinity) of a wearer in central vision. In such a configuration, as illustrated in Figure 7A, the incident light incidence angles reaching the central part of the retina are close to 0°. As the eye rotates around the CRO, the line of sight moves away from the direction of primary contemplation and the angles of incidence increase as depicted, for illustrative purposes, in Figure 7B or Figure 7C.
[00162] In this way, the multiple filtration zones of the optical lens can be configured, consequently, each filtration zone is associated with a respective cone of incidence angles of incident light on the front surface (distal surface in relation to the user) of the substrate optical, in turn, related to one or more lines of sight of the user. For each filtration zone of the example illustrated in Figure 6B, the angle of inclination of the interference edges is calculated in such a way that the main angle of incidence is a normal angle to the interference grid. For each filtration zone in this example, the target wavelength range to be rejected remains the same. Decreasing the rejection rate for each filtration zone by decentralizing the respective filtration zone on the optical substrate also contributes to the attenuation of color distortion.
[00163] Although in the specific example illustrated in Figures 6A and 6B the surface of the optical lens is provided with 4 zones, it will be seen that the surface can be provided with numerous zones without departing from the scope of the invention.
[00164] For example, modalities can be applied to different types of lenses, eg multifocal lenses. A multifocal lens has at least two optical zones with different refractive powers that can be located and controlled, i.e. a far vision portion for viewing objects at a great distance and a near vision portion for viewing objects at a close distance. In a progressive multifocal lens, the near and far portions are linked by a progression corridor that corresponds to the path followed by the eye as it passes from one zone to the other allowing the eye to move smoothly from distant vision to near vision, providing , thereby, visual comfort for the user. The near view portion and the far view portion can be associated with a reference point. The far vision reference point usually defines the intersection of the main line of sight with the lens while the near vision reference point usually defines the point on the main meridian of progression for which the power of the lens corresponds to the power required for close viewing. . Thus, in a particular embodiment of the invention as illustrated in Figure 8, a first filtration zone 722_1, i.e., a first zone of the optical substrate provided with a selective filter, can be associated with a far-viewing portion of the ophthalmic lens and a second filtering zone 722_2 may be associated with a near view portion. The first filtration zone is preferably circular or oval in shape, essentially covering the zone around the far-view reference point FV and the second filtration zone 722_2, preferably circular or oval in shape, covers the zone in around the NV near-view reference point. Furthermore, an additional zone 722_3 corresponding to the progression corridor can be provided with a selective filter according to any of the embodiments of the invention.
[00165] In the case of a progressive corrective ophthalmic lens, the diameter or largest dimension of the central zone covering the distant vision reference point is preferably between 5 and 35 mm, in particular between 10 and 25 mm and even more preferably approximately 20 mm.
[00166] The second filtration zone covering the near-view reference point is generally smaller than the one corresponding to the far-view reference point. The diameter or largest dimension of the second filtration zone covering the near vision reference point is advantageously comprised between 5 and 15 mm, preferably between 7 and 13 mm and te, in particular, approximately 10 mm. The width of the strip connecting these two zones is advantageously between 3 and 7 mm, preferably between 4 and 6 mm, and is in particular approximately 5 mm. In a particular embodiment of the invention, the band connecting the first and second zones may optionally have a selective filter that demonstrates transmission inhibition in the same target band as selective filters of either or both of the first or second zones. filtration zone.
[00167] In an additional embodiment of the invention, a contact lens can be provided with one or more filtration zones, in which the optical substrate that makes up the contact lens is provided with one or more selective interfering filters in accordance with modalities of the invention. invention. A central circular zone of the optical substrate situated at a geometric center of the lens comprises a central circular area having a diameter of 0.3 to 1 mm surrounded by one or two concentric rings, each zone having a width of about 0.5 mm. 1 mm to 1.25 mm and can be provided with respective filtering means as described above.
[00168] A method for determining the configuration of one or more selective filters for an optical lens based on a particular user or use will now be described in accordance with the particular embodiment of the invention.
[00169] In an initial step, a first set of parameters that defines at least a user's line of sight, the distance between a user's eye (from an eye reference point such as the corneal apex or the center of rotation ( CRO)) and a defined point on the optical substrate of the optical lens, such as on the posterior surface situated proximal to the wearer. In the case of use where the retina or part of the retina must be protected, the size of the retinal area centered on the fovea of the wearer's eye and/or the wearer's pupil size are also considered. For example, Figure 9A illustrates some of the parameters that can be considered, which include a distance q' from the ORC of the eye to a defined point on the back surface of optical lens 800, a distance p' between the pupil P and the ORC, and PS represents pupil size.
[00170] As previously described in relation to Figure 1E, optical lens parameters can also be considered as lens geometry (including lens thickness, center prism), where the surface equations define the front and back surfaces of the lens and the refractive index n of the optical substrate to allow the relationship between the angle of incidence of incident light on the front surface of the optical lens and the eye's line of sight to the back surface of the optical lens to be considered.
[00171] In the case of an ophthalmic lens, the first set of parameters may include spectacle wearing parameters. Such usage parameters include an eye-lens distance, pantoscopic tilt, and winding.
[00172] In general, the distance between eye and lens can be defined as the distance between a defined point on the posterior surface of the optical substrate and the center of rotation (CRO) of the eye or the corneal apex of the eye. Pantoscopic lens tilt is defined as the angle between the vertical plane and the line through the vertical edges of the lens fitted to the frame when the wearer is in a position of primary contemplation. The curl defines the angle between the horizontal line and the line through the horizontal edges of the lens fitted to the frame. In general, the pantoscopic angle can be 8°, the winding angle can be 7°, and the distance between cornea and lens is 12 mm.
[00173] Based on the first set of parameters, for each filtration zone, a cone of incidence angles is determined and each filtration zone is numerically designed considering all these incidence angles, modeling a non-collimated light source instead of be designed considering an angle of incidence (modeling a collimated light source).
[00174] Illustrative incidence cone results were obtained using a Zemax model to model the features of an eye. For example, in Figure 9C, the ophthalmic lens is a monofocal lens with a power of 0D and which has a refractive index of n = 1.591, the pantoscopic angle is 0°, the roll angle is 0°, the distance between cornea and lens is 12 mm (p' = 13 mm, q' = 25 mm), the pupil diameter is 6 mm, and the main line of sight corresponds to the direction of primary contemplation, that is, (α,β) = ( 0°.0°). In this case, by choosing to protect a retinal zone centered on the fovea of 10 mm in diameter in the vertical XY plane, it was determined that the cone of incidences in this plane is limited by dα'1 = -18° and dα'2 = +18° , which corresponds to the peripheral angles of incidence i'1 = -15.9° and i'2 = +15.9°, which corresponds to a 16 mm diameter circle centered on the optical lens reference point (Y = 0 mm) considering the peripheral rays that cross the ends of the pupil, as illustrated in Figure 9C.
[00175] In the case where the area of the retina to be protected is 4 mm, then the cone of incidences in the vertical plane is limited by dα'1 = -7° and dα'2 = +7°, which corresponds to the peripheral angles of incidences i'1 = -6.1° and i'2 = +6.1°, which corresponds to a 10.5 mm diameter circle centered on the optical lens reference point (Y = 0mm). In the case where the retinal zone to be protected is 4 mm and the main line of sight is (α,β) = (20°,0°), which means that the user rotates his eye 20° downwards, the incidence cone is still limited by dα'1 = -7° and dα'2 = +7°, but it corresponds to the peripheral angles of incidence i'1 = +9.7° and i'2 = +21.5 °, which corresponds to a zone on the lens starting from Y = -15.5 mm to Y = -4 mm on the optical lens. As mentioned before, the cone of incidences depends on numerous parameters of the optical substrate such as the lens geometry, particularly its optical power (sphere, cylinder, geometric axis, addition). The wearer's physiological parameters can also be considered as if the wearer suffers from a deterioration of the eye or should be protected against a particular deterioration of the eye. For example, a selective filter for a user suffering from AMD, Stargardt's disease, retinitis pigmentosa, Best's disease, diabetic retinopathy, Leber's optic neuropathy or glaucoma will be configured to have a selected range of incidence angles considering the size of the zone. of the retina to be protected.
[00176] In another step of the method, a second set of parameters is provided that characterizes the wavelength range to be initiated in order to determine one or more target wavelength ranges of light from which the transmission should be started.
[00177] For example, if the intended use is to protect the retina of an eye against phototoxic light, one or more selective filters may be configured to inhibit the transmission of incident light onto the front surface of the optical device of wavelengths at a width band in a range of 10 nm to 70 nm, preferably 10 nm to 60 nm centered on a wavelength in a range of 430 nm to 465 nm.
[00178] If the user suffers from a disease such as glaucoma, diabetic retinopathy, or Leber's optic neuropathy, one or more selective filters may be configured to inhibit incident light transmission in a target range that has a bandwidth of 10 to 70 nm, preferably 15 to 25 nm centered on a wavelength of about 460 nm in order to provide enhanced protection and reduce the progress of these particular diseases.
[00179] If the user suffers from a disease such as AMD, Stargardt's disease, retinitis pigmentosa, or Best's disease, one or more selective filters may be configured to inhibit incident light transmission in a target band that has a bandwidth of 10 to 70 nm, preferably 15 to 25 nm centered at a wavelength of about 435 nm in order to provide enhanced protection and reduce the progress of that particular disease.
[00180] For example, if the user suffers from a sleep-related disorder such as insomnia, fatigue from air travel, DSPS, ASPS or changes in biological rhythms due to shift work and the like, one or more selective filters may be configured to inhibit the transmission of light wavelengths in a target range of 465 nm to 495 nm centered on a wavelength of 480 nm, for example, to prevent melatonin suppression.
[00181] In the case of compensation and contrast restoration on the red-green geometry axis for a user suffering from a color vision disorder, one or more selective filters can be configured to inhibit the transmission of light wavelengths in a target range from 550 nm to 660 nm, for example.
[00182] In the case of migraine treatment or prevention, one or more selective filters can be configured to inhibit the transmission of light wavelengths in a target range of 590nm to 650nm, for example, and preferably 615- 625 nm.
[00183] In the case, for example, of treating epilepsy or preventing epileptic seizures, one or more selective filters can be configured to inhibit the transmission of light wavelengths in a target range of 560 to 600 nm.
[00184] Selective filters can be configured to be switchable so that the inhibition of the target wavelength range can be turned on and off or the rejection factor varied according to time of day or light exposure.
[00185] Depending on the target wavelength ranges, the selective interference filter as described above may be configured accordingly or the appropriate choice of absorber material described above may be carried out.
[00186] The selective filter rejection rate in the target wavelength range(s) can be configured according to the intended use and/or the required protection level.
[00187] For example, for normal preventative use for a user who does not suffer from eye disease, a relatively low rejection rate in the target wavelength range(s) may be configured, for example in the 30% to 50%. In the case of a user suffering from an eye disease like glaucoma, diabetic retinopathy or Leber's optic neuropathy, the rejection level can be increased to a level in the range of 80% to 100% for example.
[00188] The rejection rate can be adjusted by increasing the number of absorbing or interfering layers of the selective filters or by adding additional selective filters, for example, to one or both surfaces of the optical substrate. For example, a standard rejection rate according to normal preventative use could be provided for a set of optical substrates in the form of an unfinished lens, and then, during a setup phase, an additional selective, absorbing, or interfering filter could be provided. be added to an optical substrate surface during optical lens fabrication from the unfinished lens if an enhanced rejection level is required.
[00189] Furthermore, transmittance and incident light outside the target wavelength range(s) can be configured according to the required usage, for example, according to whether or not sun protection is required. . In the case of sun protection, the transmittance over the entire visible spectrum from 380 nm to 780 nm could be in the range of 8% to 100%, for example, depending on the level of sun protection required as class 0 to 3 as per defined by international standards such as NF EN 1836+A1_2007E or ISO_DIS 12312-1E. Additional filtration (interfering and/or absorbing) is set at a phototoxic target wavelength range of at least 5%. Table 1 summarizes the filter characteristics for sunscreen filters used in sun protection, according to different filter categories as set out in ISO_DIS 12312-1E


[00190] Table 1: Transmittance for sun protection filters for general use in sun protection.
[00191] Examples of specific settings are as follows for normal preventative use, e.g. against phototoxic light in at least a selected range of wavelengths, where the selective filter (interfering and/or absorbing) may be configured to inhibit light in a target range centered at 435 nm, 460 nm or 445 nm with a bandwidth of 20 nm to 60 nm with a rejection rate in the range of 30% to 50%.
[00192] For a therapeutic use, the selective filter (interfering and/or absorbing) can be configured to inhibit light in a target range centered at 435 nm, 460 nm or 445 nm with a bandwidth of 20 nm to 60 nm, with a bounce rate in the range of 80% to 100%.
[00193] For solar and preventive use, the optical device can be configured to allow transmittance of visible light over the entire visible spectrum at 8% to 60%, i.e. at an inhibition rate of 92% to 40%. The selective filter (interfering and/or absorbing) can be configured to inhibit light in a target range centered at 435 nm, 460 nm or 445 nm with a bandwidth from 25 nm to 60 nm, preferably from 25 nm to 35 nm at an additional rate of inhibition of at least 5% in addition to the rate of inhibition of visible light over the entire visible spectrum.
[00194] A lens production system for producing an optical lens in accordance with any of the embodiments of the invention may include a lens array system that includes a computer terminal on a lens array side as in an optician or attached. to a lens ordering website and a second terminal on a lens manufacturing side with the two terminals connected via data communication links. Information related to optical lens order, such as prescription values and other information required for the design and manufacture of a lens. In particular, information related to the configuration of the selective filtration medium as described above can be sent to the lens manufacturing side of the lens ordering side. For example, the type of light to be started and the degree of protection required, etc.
[00195] Fabrication of an optical lens may comprise the steps of providing an unfinished lens that has a finished curved surface and an unfinished surface. The finished curved surface can be concave (back surface in the case of an ophthalmic lens) or convex (front surface in the case of an ophthalmic lens). Typically, the unfinished surface is a concave back surface. The unfinished lens can already be fitted with a selective filter, either on the optical substrate of the unfinished lens or on a finished surface of the unfinished lens and an additional selective filter can be configured and added to the unfinished or finished surface if necessary. to enhance protection or to provide another function as described above. In a preferred embodiment, the unfinished surface is leveled before adding a selective interfering filter to the optical lens. In other cases, the unfinished lens may not yet be equipped with any selective filter and the manufacturing process may also include the configuration of a selective filter and the incorporation of the configured selective filter, inside or on the unfinished substrate before leveling, to provide a finished lens. The manufacturing process may also include the step of adding a prescription to the unfinished surface in accordance with corrective requirements for the user. Processes for making lens are described, for example, in U.S. 6,019,470 or U.S. 8,002,405.
[00196] The determination of the position of one or more filtration zones provided with selective filters on the surface of the optical element can be determined with reference to standard manufacturing marks provided as microprints on the surface of the lens including prime reference points (BP ) to facilitate prismatic power control; centering crosses (+) for positioning the lens in front of the eye and for inserting lens correction into eyeglass frames; distance waypoints (BF) and proximity waypoints (BN).
[00197] The finished surface, in the case where the finished surface is a convex front surface for an ophthalmic lens, can be a spherical surface, rotationally symmetrical spherical surface, a progressive surface, a toric surface, an atomic surface or a complex surface .
[00198] While some specific embodiments have been described above in the context of an ophthalmic lens, it will be appreciated that the invention can be applied to other optical substrates used such as windows, car and aircraft windshields, films, ophthalmic instrumentation, computer monitors , television displays, telephone screens, multimedia display displays, illuminated signs, light projectors and light sources, other ophthalmic devices and the like without departing from the scope of the invention. Ophthalmic devices may include goggles, sunglasses, eyeglasses, contact lenses, IOLs and ophthalmic lenses.
[00199] Any of the described embodiments of the invention can be used to prevent vision-related discomfort suffered by a user. An optical substrate according to any of the embodiments of the invention can be used in windows, car and aircraft windshields, films, ophthalmic instrumentation, computer monitors, television displays, telephone screens, multimedia display displays, illuminated signs , light projectors and light sources, other ophthalmic devices and the like for inhibiting the transmission of phototoxic light in at least a selected range of wavelengths to the eye of a wearer.
[00200] Optical devices comprising optical substrates in accordance with embodiments of the invention may be used, in particular, in preventing vision-related discomfort in a wearer or in therapy for providing protection to reduce the progress of disease.
[00201] Particular embodiments of the invention may be used to protect at least part of a wearer's eye against phototoxic light in the first and second selected ranges of wavelengths. For example, optical devices can be used to protect against phototoxic light in at least part of an eye of a wearer who is suffering from a deterioration of the eye, in particular, due to a degenerative process such as glaucoma, diabetic retinopathy, optic neuropathy. Leber's disease, Age-Related Macular Degeneration (AMD), Stargardt's disease, or retinitis pigmentosa. For example, an optical device according to any embodiment of the invention can be used to protect, from phototoxic light in at least a selected range of wavelengths, at least part of an eye of a user suffering from glaucoma, diabetic retinopathy or Leber's hereditary optic neuropathy, wherein the at least a selected range of wavelengths is centered on a wavelength of substantially 460 nm.
[00202] Separately or in combination with the previous example, an optical device according to embodiments of the invention can be used to protect, from phototoxic light, at least part of an eye of a user suffering from Age-Related Macular Degeneration ( AMD), Stargardt's disease, retinitis pigmentosa, or Best's disease, where at least a selected range of wavelengths is centered on a wavelength of substantially 435 nm.
[00203] In this way, the progress of the disease can be reduced by providing intensified protection.
[00204] In some embodiments, an optical device in accordance with embodiments of the invention may be used to prevent sleep disturbance and disruption of circadian rhythms due to chronobiological light-rich lighting or screens.
[00205] In other embodiments, an optical device in accordance with embodiments of the invention may be used to prevent light-induced melatonin suppression when at least a selected range of wavelengths is 465 to 495 nm. In this way, treatment that involves reducing exposure to specific wavelengths of light before sleep, often called darkness therapy, can be provided for individuals suffering from insomnia, sleep deprivation, fatigue from air travel, harmful effects on sleep due to night shift work or other sleep-related effects. Night therapy using optical devices configured in this way can be used in combination with light therapy to reset circadian rhythms in the case of DSPS or ASPS (delayed or advanced sleep phase syndrome) or other sleep-related disorders.
[00206] In additional embodiments, an optical device in accordance with embodiments of the invention may be used in the treatment of epilepsy or in the prevention of epileptic seizures when the first selected range of wavelengths is centered on a wavelength of substantially 580 nm, for example, a target wavelength range of 560 to 600 nm.
[00207] In still further embodiments, an optical device in accordance with embodiments of the invention may be used to compensate and restore contrast on the red-green geometric axis when the first selected range of wavelengths is centered on a wavelength of substantially 575 nm, for example, a target wavelength range of 550 to 600 nm.
[00208] In still further embodiments, an optical device in accordance with embodiments of the invention may be used in the treatment or prevention of migraine when the first selected range of wavelengths is centered on a target wavelength range of 590 to 650 nm, preferably 615 to 625 nm.
[00209] The wearer may be provided with ophthalmic lenses, contact lenses, IOLs, eyeglasses (eg night glasses), protective filters for computer screens or windows and the like to help reduce the progress of the disease.
[00210] While the present invention has been described herein above with reference to specific embodiments, the present invention is not limited to specific embodiments and modifications that are within the scope of the present invention will become apparent to one skilled in the art.
[00211] For example, the invention is not restricted to the described target wavelength ranges and additional examples can be provided for different applications.
[00212] The additional modifications and variations themselves will suggest to one skilled in the art by reference to the foregoing illustrative embodiments, which are given by way of example only and are not intended to limit the scope of the invention, which is determined solely by the appended claims. . In particular, different resources from different modalities may be interchanged where appropriate.
[00213] In the claims, the term "which comprises" does not exclude other elements or steps and the indefinite article "a" or "an" does not exclude a plurality. The mere fact that different features are recited in mutually different dependent claims does not indicate that a combination of these features cannot be used to advantage. Any reference sign in the claims should not be interpreted as limiting the scope of the invention.

权利要求:
Claims (31)
[0001]
1. Method characterized by determining the configuration of interfering filtering media for an optical device in order to customize the optical device for a user of the optical device, wherein the method comprises: receiving as user-specific input a first set of parameters representative of i) at least one primary line of sight of the user, ii) the distance between the optical substrate of the optical device and a user's eye, and iii) a size of a retinal area to be protected from the retina of the eye of the user. user, the size of the retinal area being less than a whole retina; determining a first selected range of angles of incidence based on the first set of user-specific parameters; providing a second set of parameters characterizing, user-specific, a range of wavelengths to be partially inhibited; determining a first selected range of incident light wavelengths to be inhibited by the optical device, at least partially, based on the second set of user-specific parameters; and configuring a first selective interfering filter means and a first zone of a surface of the optical substrate based on the first selected range of determined angles of incidence and the first selected range of determined wavelengths, such that the first filtering means selective interference is operable to inhibit, at a first rejection rate, transmission of the first selected range of wavelengths of determined incident light in the first zone within the first selected range of determined angles of incidence, thus to customize the optical device for the user , wherein the step of determining a first selected range of angles of incidence includes defining said range of angles by all angles of incidence between the angles of incidence of peripheral rays of light reaching the margins of the retinal area of the user's eye, in that the first set of parameters are aimed at protecting the area retinal of the user's eye, and the angles of incidence are determined relative to the retinal area to be protected and without incorporating a portion outside the retinal area to be protected.
[0002]
Method according to claim 1, characterized in that the first and/or the second set of parameters additionally comprises physiological parameters of the user.
[0003]
A method as claimed in claim 2, wherein the wearer's physiological parameters include any of whether the wearer suffers from eye deterioration or should be protected from eye deterioration.
[0004]
A method according to claim 1, characterized in that it further comprises: providing at least a first additional set of parameters representative of i) at least one additional main user's line of sight, ii) the distance between the optical substrate and the wearer's eye, and iii) the size of at least one of an area of retina centered on the fovea of the wearer's eye and the pupil size of the wearer's eye; determining, for each additional first set of parameters, a respective selected range of angles of incidence based on the respective first additional set of parameters; providing at least a second additional set of parameters that characterize, to the user, at least an additional range of wavelengths to be at least partially inhibited; determining, for each second additional parameter set, a respective selected range of incident light wavelengths to be inhibited, at least partially, based on the respective second additional parameter set; and for each additional first parameter set and additional second parameter set: configure a respective additional selective interfering filter media and a respective additional optical substrate surface zone based on the respective selected range of incidence angles and the respective selected range of wavelengths such that the respective additional selective interfering filtering means is operable to inhibit, at a respective additional rejection rate, the transmission of the respective selected range of wavelengths of incident light incident on the respective additional zone within the respective wavelength. selected range of angles of incidence.
[0005]
Method according to claim 4, characterized in that each respective selected range of incidence angles is different from the first selected range of incidence angles.
[0006]
Method according to claim 4, characterized in that each respective wavelength selective range is substantially equal to the first selected wavelength range.
[0007]
7. Method according to claim 1, characterized in that the first rejection rate is in a range of 10% to 100%.
[0008]
Method according to claim 4, characterized in that each additional bounce rate is different from the first bounce rate.
[0009]
A method as claimed in claim 4, wherein the optical device is an optical lens, the method further comprising configuring the first zone to correspond to a far view portion of the optical lens for a wearer and an additional zone. to match a near-view portion of the optical lens for a wearer.
[0010]
A method according to claim 1, characterized in that it further comprises configuring each selective interfering filtration means to inhibit incident light transmission by at least one of reflection, refraction and diffraction.
[0011]
A method according to claim 1, characterized in that the first selected range of wavelengths has a bandwidth in the range of 10 nm to 70 nm.
[0012]
A method according to claim 11, characterized in that the first selected range of wavelengths has a bandwidth in a range of 20 nm to 60 nm, and the first rejection rate is in a range of 10 to 60 nm. 50%.
[0013]
Method according to claim 11, characterized in that the first selected range of wavelengths has a bandwidth in a range of 15 nm to 30 nm, and the first rejection rate is in a range of 60 to 30 nm. 100%.
[0014]
Method according to claim 11, characterized in that the optical device is configured to inhibit the transmission of visible light across the entire visible spectrum at an inhibition rate in a range of 40% to 92%, the first range selected range of wavelengths has a bandwidth in the range of 25 nm to 60 nm, and the first reject rate is set to provide at least 5% additional inhibition for the first selected range of wavelengths.
[0015]
Method according to claim 1, characterized in that the first selected range of wavelengths is from 465 nm to 495 nm.
[0016]
Method according to claim 1, characterized in that the first selected range of wavelengths is from 550 nm to 660 nm.
[0017]
Method according to claim 1, characterized in that the first selected range of wavelengths is from 590 nm to 650 nm.
[0018]
Method according to claim 1, characterized in that the first selected range of wavelengths is from 560 nm to 600 nm.
[0019]
19. Method of manufacturing an optical lens, the method comprising the steps of providing a semi-finished optical lens having an unfinished surface and an opposing surface, wherein the unfinished surface is one of a convex surface and a concave surface and the opposite surface is the other of a convex surface and a concave surface; determining a configuration of a selective interfering filter media for the optical lens for a wearer; level the unfinished surface; providing one of the surfaces with the selective interfering filtration medium; and wherein the step of determining a configuration of selective interfering filtration media comprises a method of determining the configuration of selective interfering filtration media as defined in claim 1.
[0020]
Method according to claim 5, characterized in that each respective wavelength selective range is substantially equal to the first selected wavelength range.
[0021]
The method of claim 5, characterized in that the optical device is an optical lens, the method further comprising configuring the first zone to correspond to a far view portion of the optical lens for a wearer and an additional zone to correspond to a near-view portion of the optical lens for a wearer.
[0022]
22. Method according to claim 7, characterized in that the first rejection rate is in a range of 30 to 100%.
[0023]
Method according to claim 11, characterized in that the first selected band has a bandwidth in a range of 10 nm to 60 nm centered on a wavelength within the range of between 430nm and 465nm.
[0024]
Method according to claim 12, characterized in that the first selected range of wavelengths has a bandwidth in a range of 20 nm to 25 nm centered on a wavelength of one of 435nm, 445nm and 460nm. .
[0025]
25. Method according to claim 12, characterized in that the first rejection rate is in a range of 30 to 50%.
[0026]
Method according to claim 13, characterized in that the first selected range of wavelengths has a bandwidth in a range of 15 nm to 25 nm centered on a wavelength of one of 435nm, 445nm and 460nm. .
[0027]
27. Method according to claim 13, characterized in that the first rejection rate is in a range of 80 to 100%.
[0028]
A method as claimed in claim 14, characterized in that the first selected range of wavelengths has a bandwidth in a range of 25 nm to 35 nm centered on a wavelength of one of 435nm, 445nm and 460nm. .
[0029]
Method according to claim 17, characterized in that the first selected range of wavelengths is from 615 nm to 625 nm.
[0030]
A method according to claim 1, characterized in that the step of providing a first set of parameters also includes a pupil size of the user's eye.
[0031]
Method according to claim 3, characterized in that the deterioration of the eye is due to degenerative mechanisms such as oxidative stress.

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JP2015509742A|2015-04-02|

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KR20140104997A|2014-08-29|

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JP2020157071A|2020-10-01|

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WO2013084176A1|2013-06-13|

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法律状态:
2018-07-17| B25A| Requested transfer of rights approved|Owner name: UNIVERSITE PARIS 6 PIERRE ET MARIE CURIE (FR) ; ES |

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2018-12-04| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-05-07| B25A| Requested transfer of rights approved|Owner name: ESSILOR INTERNATIONAL (FR) ; SORBONNE UNIVERSITE ( Owner name: ESSILOR INTERNATIONAL (FR) ; SORBONNE UNIVERSITE (FR) |

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2020-04-07| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2021-06-01| B350| Update of information on the portal [chapter 15.35 patent gazette]|

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2021-11-03| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2022-01-11| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/12/2012, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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EP11306630.2A|EP2602653B1|2011-12-08|2011-12-08|Method of determining the configuration of an ophthalmic filter|

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EP11306630.2|2011-12-08|

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PCT/IB2012/057013|WO2013084176A1|2011-12-08|2012-12-06|Method of determining the configuration of an ophthalmic filter|

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